A prospective study of delusional misidentification syndromes in Parkinson's disease with dementia
Identifieur interne : 002A29 ( Main/Exploration ); précédent : 002A28; suivant : 002A30A prospective study of delusional misidentification syndromes in Parkinson's disease with dementia
Auteurs : Javier Pagonabarraga [Espagne] ; Gisela Llebaria [Espagne] ; Carmen García-Sánchez [Espagne] ; Berta Pascual-Sedano [Espagne] ; Alexandre Gironell [Espagne] ; Jaime Kulisevsky [Espagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-02-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Prospective.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Cholinesterase Inhibitors (therapeutic use), Delusions (drug therapy), Delusions (etiology), Dementia, Dementia (complications), Dementia (diagnosis), Female, Hallucination, Humans, Male, Nervous system diseases, Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (diagnosis), Parkinson disease, Parkinson's disease, Prospective, Prospective Studies, delusional misidentification, dementia, familiarity, hallucinations.
- MESH :
- chemical , therapeutic use : Cholinesterase Inhibitors.
- complications : Dementia, Parkinson Disease.
- diagnosis : Dementia, Parkinson Disease.
- drug therapy : Delusions.
- etiology : Delusions.
- Aged, Aged, 80 and over, Female, Humans, Male, Neuropsychological Tests, Prospective Studies.
Abstract
Delusional misidentification syndromes (DMS) are a group of neuropsychiatric disorders due to disturbances in familiarity. DMS in organic diseases have been related to deficits in executive, memory, and visuospatial function. DMS are frequently reported in dementia with Lewy bodies (DLB). The presence of DMS in Parkinson's disease with dementia (PDD), which shares similar clinical and neuropsychological features with DLB, has not been studied. We describe the frequency and clinical features of DMS in a cohort of PDD patients, and we compare the neuropsychological profile between PDD patients with and without DMS. Prospective study of 30 PDD patients recruited from an outpatient setting, who received a structured behavioral interview assessing DMS and hallucinations, and a neuropsychological battery assessing executive function, memory, language, and visuospatial abilities. DMS were found in 16.7% of PDD patients. All DMS subjects also exhibited hallucinations that were significantly more severe than in PDD without DMS. DMS were responsive to neuroleptic drugs. PDD subjects with DMS presented a different neuropsychological profile than PDD subjects without DMS, with more severe memory and language deficits, but similar levels of executive and visuospatial impairment. DMS is a neuropsychiatric feature associated with PDD. Greater impairment in language and memory in PDD with DMS suggests a prominent role of the temporal cortex in the genesis of DMS in PDD. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21864
Affiliations:
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Le document en format XML
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DMS in organic diseases have been related to deficits in executive, memory, and visuospatial function. DMS are frequently reported in dementia with Lewy bodies (DLB). The presence of DMS in Parkinson's disease with dementia (PDD), which shares similar clinical and neuropsychological features with DLB, has not been studied. We describe the frequency and clinical features of DMS in a cohort of PDD patients, and we compare the neuropsychological profile between PDD patients with and without DMS. Prospective study of 30 PDD patients recruited from an outpatient setting, who received a structured behavioral interview assessing DMS and hallucinations, and a neuropsychological battery assessing executive function, memory, language, and visuospatial abilities. DMS were found in 16.7% of PDD patients. All DMS subjects also exhibited hallucinations that were significantly more severe than in PDD without DMS. DMS were responsive to neuroleptic drugs. PDD subjects with DMS presented a different neuropsychological profile than PDD subjects without DMS, with more severe memory and language deficits, but similar levels of executive and visuospatial impairment. DMS is a neuropsychiatric feature associated with PDD. Greater impairment in language and memory in PDD with DMS suggests a prominent role of the temporal cortex in the genesis of DMS in PDD. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Espagne</li></country></list><tree><country name="Espagne"><noRegion><name sortKey="Pagonabarraga, Javier" sort="Pagonabarraga, Javier" uniqKey="Pagonabarraga J" first="Javier" last="Pagonabarraga">Javier Pagonabarraga</name></noRegion><name sortKey="Garcia Nchez, Carmen" sort="Garcia Nchez, Carmen" uniqKey="Garcia Nchez C" first="Carmen" last="García-Sánchez">Carmen García-Sánchez</name><name sortKey="Gironell, Alexandre" sort="Gironell, Alexandre" uniqKey="Gironell A" first="Alexandre" last="Gironell">Alexandre Gironell</name><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name><name sortKey="Llebaria, Gisela" sort="Llebaria, Gisela" uniqKey="Llebaria G" first="Gisela" last="Llebaria">Gisela Llebaria</name><name sortKey="Pascual Edano, Berta" sort="Pascual Edano, Berta" uniqKey="Pascual Edano B" first="Berta" last="Pascual-Sedano">Berta Pascual-Sedano</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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